The story of this video begun in the year 2015, when Irina Alexeenko, an ambitious scientist came to us with a proposal to help their team of scientists with the demonstration of a conceptual new antitumor gene therapy drug. BiotechMedaccelerator gave a boost to this promising idea.

Together, we created this video to take part in a competition called Generation Sorganised by the Government fund of funds Development institute of the Russian Federation. The level of competition was extremely high. Finally, this #startup won the first prize and received a grant for future trials. We were proud to witness this incredible moment when our colleagues got their most significant achievement. We aimed to make a realistic animation to help scientists portray a complex mechanism of action of AntionkoRAN-M. Our collective efforts proved to be a smashing success.

AntionkoRAN-M is a conceptual drug. It passed clinical trials in the Hertsen scientific institute in Moscow. These trials have shown high antitumor efficacy: increase in life expectancy from 72-86%, inhibition of tumor growth 75-83%, inhibition of metastasis 80-85%, depending on the type of tumor. The drug is designed for the treatment of head and neck cancer, cervical cancer and colorectal cancer.

AntionkoRAN-M is a nanoparticle with a polycationic coating, which contains anti-tumor DNA. The active part of this DNA consists of a suicide gene and cytokine gene encoding an immuno-stimulator. Upon entering the tumor, the suicide gene activates the synthesis of a toxin that kills cancer cells, and the product of the immuno-stimulator attracts immune cells to the tumor. The combination of suicide gene and immuno-stimulator destroys cancer cells and activates a specific immune response. As a result, there is a significant decrease in the tumor growth and reduction of distant metastases.

You can watch detailed information about this animation on our webpage 

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