Strategies to optimize tacrolimus treatment and improve long-term clinical outcomes in solid organ transplantation

N. Shuker

More than sixty years have elapsed since the first successful human kidney transplantation and this procedure has become the treatment of choice for patients with end-stage renal disease. Although the development of powerful and specific immunosuppressive drugs has contributed to the success of this therapy, several challenges remain. Patients still suffer from rejections and kidney allograft loss, while they are also at increased risk of severe infectious complications, cancer and other immunosuppressive drug-related toxicity. In this thesis we tried to find strategies to optimize the immunosuppressive therapy with tacrolimus (TAC) with the primary goal to improve the (long-term) outcomes of solid organ transplantation.

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