Abstract of the article (doi: 10.1016/j.isci.2022.105188) where this scientific illustration was published:

Cell proliferation is dependent on growth factors insulin and IGF1. We sought to
identify interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling,
that regulate cell proliferation. Using proximity-dependent biotin identification
(BioID), we detected 40 proteins displaying proximal interactions with IRS1,
including DCAF7 and its interacting partners DYRK1A and DYRK1B. In HepG2
cells, DCAF7 knockdown attenuated cell proliferation by inducing cell cycle arrest
at G2. DCAF7 expression was required for insulin-stimulated AKT phosphorylation,
and its absence promoted nuclear localization of the transcription factor
FOXO1. DCAF7 knockdown induced expression of FOXO1-target genes implicated
in G2 cell cycle inhibition, correlating with G2 cell cycle arrest. In Drosophila
melanogaster,wing-specificknockdownofDCAF7/wap caused smaller wing size
and lower wing cell number; the latter recovered upon double knockdown of wap
and dfoxo. We propose that DCAF7 regulates cell proliferation and cell cycle via
IRS1-FOXO1 signaling, of relevance to whole organism growth.