Relationship between mitochondria dysfunction and lung diseases (Fang et al., 2019).

Mitochondrial dysfunction is rapidly developing as a key pathological feature of early and persistent lung disease. In particular, mitochondria are emerging as central to the pathological processes and clinical phenotypes associated with a range of lung diseases.

Abnormal mitochondrial signaling plays an important role in many lung diseases:

1.Altered mitochondrial biogenesis and mitogenesis

2.Increased mtDNA mutations

3.Abnormal mitochondrial-derived signaling

4.Activation of mtDAMPs

Comprehending the molecular mechanisms that modulate mitochondrial processes in lung cells will allow for a better definition of the phenotypes and clinical manifestations associated with respiratory diseases and explore potential diagnostic and therapeutic targets.