Treat Malaria with Hydroxychloroquine.

Malaria is also called as Jungle fever.

The essential hypothesis behind its adequacy against jungle fever lies in its capacity to obstruct the detoxification interaction in the plasmodium parasites.

The jungle fever parasites (plasmodium) first attack the RBC and afterward ingest hemoglobin from the cytosol into the food vacuole. Then, at that point, it involves the decayed hemoglobin for blending amino acids proteins for its development. The disintegrated hemoglobin (comprises of ferriprotoporphyrin IX (FPIX) haematin) ultimately changed into nontoxic solidified polymers named hemozoin.

The food vacuole is a lysosomal disengaged acidic compartment, and the HCQ is a feeble soluble. Thus, HCQ diffuses the vacuole layer and transform itself into a protonated structure, which the parasite can't diffuse out.

The amassed HCQ in the food vacuole undermines the FPIX, consequently hindering its polymerization, prompting parasite cell lysis.

Another hypothesis proposes that HCQ focuses on the core, not the lysosome. It can straightforwardly cooperate or tie to the parasite's DNA and RNA and hinders its replication and record process.