The Type IV Secretion System (T4SS) is a potent weapon used by some bacteria to infect their host and can deliver effector proteins into eukaryotic cells as well as DNA and/or toxins into bacterial neighbors. T4SSs are deployed by a variety of human pathogens, such as Legionella pneumophila, Helicobacter pylori, and Bordetella pertussis. Legionella pneumophila is an opportunistic pathogen that causes the potentially fatal pneumonia Legionnaires’ Disease. This infection and subsequent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins into host cells. Compared to prototypical T4SSs, the Dot/Icm assembly is much larger, containing ~27 different components including a core complex reported to be composed of five proteins: DotC, DotD, DotF, DotG, and DotH. Here you can admire the structure of the Legionella Dot/Icm T4SS system determined by single particle CryoEM (PDB code: 7MUW)
#molecularart ... #immolecular ... #Legionella ... #infection ... #type4 ... #secretion ... #system ... #pathogenesis ... #cryoem
Rendered with @proteinimaging and composed by @corelphotopaint
#molecularart ... #immolecular ... #Legionella ... #infection ... #type4 ... #secretion ... #system ... #pathogenesis ... #cryoem
Rendered with @proteinimaging and composed by @corelphotopaint
