Across different kingdoms of life, ATP citrate lyase (ACLY, also known as ACL) catalyses the ATP-dependent and coenzyme A (CoA)-dependent conversion of citrate, a metabolic product of the Krebs cycle, to oxaloacetate and the high-energy biosynthetic precursor acetyl-CoA. The latter fuels pivotal biochemical reactions such as the synthesis of fatty acids, cholesterol and acetylcholine, and the acetylation of histones and proteins. In autotrophic prokaryotes, ACLY is a hallmark enzyme of the reverse Krebs cycle (also known as the reductive tricarboxylic acid cycle), which fixates two molecules of carbon dioxide in acetyl-CoA. Here you can see a recent high resolution structure of a citrate lyase from the metanogenic archaea Methanothrix soehngenii (PDB code: 6ZNW)
#molecularart ... #immolecular ... #citrate ... #lyase ... #archaea ... #metanogenic ... #Xray ... Rendered with @proteinimaging and finished with @corelphotopaint
#molecularart ... #immolecular ... #citrate ... #lyase ... #archaea ... #metanogenic ... #Xray ... Rendered with @proteinimaging and finished with @corelphotopaint
