The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (also known as AMPA receptor, AMPAR, or quisqualate receptor) is an ionotropic transmembrane receptor for glutamate that mediates fast synaptic transmission in the central nervous system (CNS). It has been traditionally classified as a non-NMDA-type receptor, along with the kainate receptor. Its name is derived from its ability to be activated by the artificial glutamate analog AMPA. The receptor was first named the "quisqualate receptor" by Watkins and colleagues after a naturally occurring agonist quisqualate and was only later given the label "AMPA receptor" after the selective agonist developed by Tage Honore and colleagues at the Royal Danish School of Pharmacy in Copenhagen. Here you can see a recent CryoEM structure of the human AMPA receptor in complex with TARP gamma 8 and CNIH2 (PDB code: 7OCF)
#molecularart ... #immolecular ... #receptor ... #AMPA ... #membrane ... Rendered with @proteinimaging and polished with @corelphotopaint
#molecularart ... #immolecular ... #receptor ... #AMPA ... #membrane ... Rendered with @proteinimaging and polished with @corelphotopaint
